Pyridazinones. 1. Synthesis, antisecretory, and antiulcer activities of thio amide derivatives

T Yamada, Y Nobuhara, A Yamaguchi…

Index: Yamada; Nobuhara; Yamaguchi; Ohki Journal of Medicinal Chemistry, 1982 , vol. 25, # 8 p. 975 - 982

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Citation Number: 17

Abstract

In an effort to develop new types of antiulcer agents, a series of novel 3 (2H)-pyridazinone derivatives and related analogues was synthesized. Substituted 3 (2H)-pyridazinones and their 4, bdihydro analogues were alkylated by w-haloalkyl cyanides at the N-2 position under phase-transfer catalytic reaction, and the nitrile group was converted to the thio amide group by treatment with hydrogen sulfide alone or with the appropriate primary or ...