A new boronic-acid based strategy to synthesize 4 (5)-(het) aryl-1H-imidazoles

N Primas, C Mahatsekake, A Bouillon, JC Lancelot…

Index: Primas, Nicolas; Mahatsekake, Clement; Bouillon, Alexandre; Lancelot, Jean-Charles; Oliveira Santos, Jana Sopkova-de; Lohier, Jean-Francois; Rault, Sylvain Tetrahedron, 2008 , vol. 64, # 20 p. 4596 - 4601

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Citation Number: 27

Abstract

In the last decade, very much attention has been paid to the development of efficient methods for the preparation of 4(5)-aryl substituted imidazole derivatives because of their important biological and pharmacological properties. A recent review of Bellina et al. 1 reported biological properties such as antifungal activity, 2 potent β-glucosidase 3 or activin receptor-like kinase 5 (ALK5) inhibitors. 4 Relatively few methods to access the title compounds are described. ...