Microbiological systems in organic synthesis: preparation of racemic prenalterol utilizing Cunninghamella echinulata

FM Pasutto, NN Singh, F Jamali…

Index: Pasutto; Singh; Jamali; Coutts; Abuzar Journal of Pharmaceutical Sciences, 1987 , vol. 76, # 2 p. 177 - 179

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Citation Number: 11

Abstract

Abstract The fungal microorganism Cunninghamella echinulata was utilized to para- hydroxylate the synthetic substrate (±)-1-isopropylamino-3-phenoxy-propan-2-ol (1). The resulting product,(±)-1-(4-hydroxyphenoxy)-3-isopropylamino-propan-2-ol, or (±)- prenalterol,(2) was formed in> 85% yield. Extracts from incubates were derivatized with trifluoroacetic anhydride and the concentrations of 1 and 2 were determined by GC on a ...