Anti-coxsackievirus B3 activity of 2-amino-3-nitropyrazolo [1, 5-a] pyrimidines and their analogs

…, HM Dahse, A Stelzner, P Wutzler, M Schmidtke

Index: Makarov, Vadim A.; Riabova, Olga B.; Granik, Vladimir G.; Dahse, Hans-Martin; Stelzner, Axel; Wutzler, Peter; Schmidtke, Michaela Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 1 p. 37 - 39

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Citation Number: 37

Abstract

A novel class of 2-amino-4-nitropyrazolo [1, 5-a] pyrimidines has been identified as potent inhibitors of coxsackievirus B3 replication. The synthesis of these compounds is based on the regioselective reaction of 3, 5-diamino-5-nitropyrazole with unsymmetrical β-diketones at catalysis by hydrochloric acid leading to 2-amino-4-nitropyrazolo [1, 5-a] pyrimidines as key steps.