Organic letters

N-heterocyclic carbene-catalyzed amidation of unactivated esters with amino alcohols

M Movassaghi, MA Schmidt

Index: Movassaghi, Mohammad; Schmidt, Michael A. Organic Letters, 2005 , vol. 7, # 12 p. 2453 - 2456

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Citation Number: 227

Abstract

Synthesis of amides is important in many areas of chemistry, including peptide, polymer, and complex molecule synthesis. 1 Condensation products of optically active amino alcohols and carboxylic acids are of particular significance due to their impact in stereoselective synthesis. 2 Dehydration (and oxidation) of N-hydroxyalkyl amides affords valuable heterocycles that are present in many biologically active natural products. 3 Mild methods for the ...

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