Synthesis and structure-activity relationships of 7-diazabicycloalkylquinolones, including danofloxacin, a new quinolone antibacterial agent for veterinary medicine

…, DD Mann, NC Elliott, P Chang, EP Cisek…

Index: McGuirk; Jefson; Mann; Elliott; Chang; Cisek; Cornell; Gootz; Haskell; Hindahl; LaFleur; Rosenfeld; Shryock; Silvia; Weber Journal of Medicinal Chemistry, 1992 , vol. 35, # 4 p. 611 - 620

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Citation Number: 49

Abstract

A series of novel 6-fluoro-7-diazabicycloalkylquinolonecarboxylic acids substituted with various C8 (H, F, C1, N) and N1 (ethyl, cyclopropyl, vinyl, 2-fluoroethyl, 4-fluorophenyl, 2, 4- difluorophenyl) substituents, as well as, 9-fluoro-lO-diazabicycloalkylpyridobenzoxazinecarboxy... acids, were prepared and evaluated for antibacterial activity against a range of important veterinary pathogenic bacteria. The diazabicycloalkyl side chains investigated at the 7- ...