Synthesis of quinolinomorphinan-4-ol derivatives as δ opioid receptor agonists

…, T Nakamura, T Kanemasa, A Kato, H Nagase

Index: Ida, Yoshihiro; Nemoto, Toru; Hirayama, Shigeto; Fujii, Hideaki; Osa, Yumiko; Imai, Masayuki; Nakamura, Takashi; Kanemasa, Toshiyuki; Kato, Akira; Nagase, Hiroshi Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 2 p. 949 - 961

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Citation Number: 27

Abstract

The previously reported morphinan derivative SN-28 showed high selectivity and agonist activity for the δ opioid receptor. In the course of examining the structure–activity relationship of SN-28 derivatives, the derivatives with the 4-hydroxy group (SN-24, 26, 27) showed higher selectivities for the δ receptor over the μ receptor than the corresponding SN-28 derivatives with the 3-hydroxy group (SN-11, 23, 28). Derivatives with the 4-hydroxy group ...