Synthesis of amino acids and related compounds. 6. New convenient synthesis of. alpha.-C-acylamino acids and. alpha.-amino ketones

M Suzuki, T Iwasaki, M Miyoshi…

Index: Suzuki,M. et al. Journal of Organic Chemistry, 1973 , vol. 38, p. 3571 - 3575

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Citation Number: 59

Abstract

aC-Acylamino acid esters (3-oxo-2-amino acid esters, 6) were prepared in good yields by the acid hydrolysis of a-acyl-a-isocyanoacetate analogs (5) and oxazole-4-carboxylate derivatives (4), which were easily obtained by the reaction cf a-isocyanoacetate analogs (1) with acyl halides (2) or acid anhydrides (3) in the presence of metallic or organic bases. Further, the hydrolysis of 6 and 4 gave the a-amino ketones (7) in high yields.