Anticancer siRNA delivery by new anticancer molecule: A novel combination strategy for cancer cell killing

PR Muktapuram, RK Gara, K Sharma, C Rohit…

Index: Muktapuram, Prathap Reddy; Gara, Rishi Kumar; Sharma, Komal; Rohit, Chilappa; Srinivas, Kolupula; Mishra, Durga Prasad; Bathula, Surendar Reddy European Journal of Medicinal Chemistry, 2012 , vol. 56, p. 400 - 408

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Citation Number: 9

Abstract

The present report describes development of a novel, bifunctional molecule possessing both selective antiproliferative activity and siRNA transfection ability. We synthesized a series of cationic lipo-benzamides and screened for in vitro anticancer activities against a panel of cancer and non-cancer cells. The molecule with a ten carbon chain-length (C10M) significantly inhibited proliferation of cancer cells via arresting the cell cycle predominantly ...

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