Development of two complementary syntheses for a privileged CGRP receptor antagonist substructure

DK Leahy, LV Desai, RP Deshpande…

Index: Organic Process Research and Development, , vol. 16, # 2 p. 244 - 249

Full Text: HTML

Citation Number: 9

Abstract

... Organic Process Research & Development. ... In-process solution yields. ... Citric acid was found to be a sufficiently mild acid to effect the desired transformation, and a telescoped procedure was developed to avoid an additional isolation step.(21) Hence, upon subjection of 13 to the ...