Ultrasound-based approach to spiro-2, 3-dihydroquinazolin-4 (1H)-ones: their in vitro evaluation against chorismate mutase

D Rambabu, SK Kumar, BY Sreenivas, S Sandra…

Index: Rambabu; Kiran Kumar; Yogi Sreenivas; Sandra, Sandhya; Kandale, Ajit; Misra, Parimal; Basaveswara Rao; Pal, Manojit Tetrahedron Letters, 2013 , vol. 54, # 6 p. 495 - 501

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Citation Number: 24

Abstract

Amberlyst-15 has been identified as a green and reusable catalyst in the synthesis of spiro 2, 3-dihydroquinazolin-4 (1H)-ones under ultrasound irradiation at room temperature. The reaction can be performed in an open flask as the conversion was found to be not sensitive to the presence of air or atmospheric moisture. The methodology was found to be general and a wide variety of spiro 2, 3-dihydroquinazolin-4 (1H)-ones were prepared from 2- ...

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