Design, synthesis and in vivo anticonvulsant screening in mice of Novel phenylacetamides

AV Shindikar, F Khan, CL Viswanathan

Index: Shindikar; Khan; Viswanathan European Journal of Medicinal Chemistry, 2006 , vol. 41, # 6 p. 786 - 792

Full Text: HTML

Citation Number: 35

Abstract

A set of seven novel N-substituted 2-anilinophenylacetamides were designed by pharmacophore generation and using flexible alignment module of MOE software. The novel molecules were synthesized and screened for anticonvulsant activity in Swiss albino mice by MES and ScPTZ induced seizure tests. Test compounds were found to be potent in MES test. Compounds 12 and 14 were found to be more potent with ED50 values 24.0 ...

Related Articles:

Ultrasound-based approach to spiro-2, 3-dihydroquinazolin-4 (1H)-ones: their in vitro evaluation against chorismate mutase

[Rambabu; Kiran Kumar; Yogi Sreenivas; Sandra, Sandhya; Kandale, Ajit; Misra, Parimal; Basaveswara Rao; Pal, Manojit Tetrahedron Letters, 2013 , vol. 54, # 6 p. 495 - 501]

Selenium??Promoted Intramolecular Oxidative Amidation of 2??(Arylamino) acetophenones for the Synthesis of N??Arylisatins

[Liu, Yong; Chen, Hui; Hu, Xiong; Zhou, Wang; Deng, Guo-Jun European Journal of Organic Chemistry, 2013 , # 20 p. 4229 - 4232]

Ruthenium (II) porphyrin-catalyzed amidation of aromatic heterocycles

[He, Ling; Chan, Philip Wai Hong; Tsui, Wai-Man; Yu, Wing-Yiu; Che, Chi-Ming Organic Letters, 2004 , vol. 6, # 14 p. 2405 - 2408]

Synthesis of N-Arylisatins using NaY Heterogeneous Catalyst under Microwave Irradiations

[Singh, Ravinder; Kumar, Ramesh Oriental Journal of Chemistry, 2012 , vol. 28, # 2 p. 1049 - 1054]

A New, Efficient and Recyclable Lanthanum (III) Oxide??Catalyzed C N Cross??Coupling

[Murthy, S. Narayana; Madhav; Reddy, V. Prakash; Nageswar Advanced Synthesis and Catalysis, 2010 , vol. 352, # 18 p. 3241 - 3245]

More Articles...