Synthesis of 2'-deoxyuridine and 5-fluoro-2'-deoxyuridine derivatives and evaluation in antibody targeting studies

…, SR Chhabra, BW Bycroft, RW Baldwin

Index: Henn; Garnett; Chhabra; Bycroft; Baldwin Journal of Medicinal Chemistry, 1993 , vol. 36, # 11 p. 1570 - 1579

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Citation Number: 25

Abstract

Derivatives of 2'-deoxyuridine and of the anticancer agent 5-fluoro-2'-deoxyuridine (FdUR) were linked indirectly via a human serum albumin carrier (HSA) to the murine antiosteosarcoma monoclonal antibody 791T/36. Starting from the 2'-deoxyuridines la and lb, the new nucleosides containing 5'-succinamic acid 7 and 5'-maleamic acid 8 spacers were synthesized from the key intermediate 5'-aminonucleoside 4, and the ...