Journal of medicinal chemistry

Potential thyroliberin affinity labels. 1. Chloroacetyl-substituted phenylalanylpyrrolidines

RJ Goebel, BL Currie, CY Bowers

Index: Goebel, Richard J.; Currie, Bruce L.; Bowers, Cyril Y. Journal of Medicinal Chemistry, 1981 , vol. 24, # 4 p. 366 - 370

Full Text: HTML

Citation Number: 5

Abstract

Six analogues of thyroliberin (TRH) that have a chloroacetyl substituent at the amino terminus have been prepared as potential affinity labels for the TRH receptor. These compounds are N-(chloroacety1)-L-alanyl-L-phenyl-alanylpyrrolidine (ClAoAla-PhePyrr; 141, N-[m-(ehloroacetyl) bemyl]-bphenylalanylpyr~~ lidine (m-CMdbPhe-Pyrr; 1 la), N-[m- (chloroacetyl) benzoy1]-~-alanyl-~-pheny~ ylpyrrolidine (m-ClAcBz-Ala-Phe-Pyrr; 15a), N- ...