Chemoenzymatic synthesis and resolution of compounds containing a quaternary stereocenters adjacent to a carbonyl group

T Mahapatra, N Jana, S Nanda

Index: Mahapatra, Tridib; Jana, Nandan; Nanda Tetrahedron Asymmetry, 2008 , vol. 19, # 10 p. 1224 - 1232

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Citation Number: 22

Abstract

Racemic compounds containing a quaternary stereocenter (having hydroxymethyl and alkyl group adjacent to keto functionality) based on chromanone, α-tetralone, and indalone scaffolds have been synthesized. An enzymatic irreversible transesterification approach has been applied to generate the pure enantiomers in a stereocontrolled fashion. The pure enantiomers of some α, α-dialkylated carbonyl compounds have been synthesized by this ...