Tetrahedron letters

A simple method of preparation of 7-alkyl-7-azabicyclo [2.2. 1] heptanes

A Hassner, AM Belostotskii

Index: Hassner, Alfred; Belostotskii, Anatoly M. Tetrahedron Letters, 1995 , vol. 36, # 10 p. 1709 - 1712

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Citation Number: 19

Abstract

Action of triphenylphosphine-carbon tetrachloride on the trans-4-alkylaminocyclohexanols leads to 7-alkyl-7-azabicyclo [2.2. 1] heptanes in the good yields. The starting aminoalcohols are easily available from the monoethylene ketal of 1, 4-cyclohexanedione and primary amines in a four step process without isolation of intermediates.