Base??Mediated Direct Arylation of Pyrrole Derivatives

O Vakuliuk, B Koszarna…

Index: Vakuliuk, Olena; Koszarna, Beata; Gryko, Daniel T. Advanced Synthesis and Catalysis, 2011 , vol. 353, # 6 p. 925 - 930

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Citation Number: 35

Abstract

Abstract It appears that transition metal catalysts are not necessary to perform the direct arylation of electron-rich heterocycles with aryl iodides and bromides. Lithium tert-butoxide in DMF promotes this reaction for a variety of N-alkyl-and N-arylpyrroles as well as for benzofuran and some other electron-rich aromatic compounds and provides the desired products in moderate to high yields. In contrast to all previous reports on the Pd-catalyzed ...

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