Synthesis of the antitumoural agent batracylin and related isoindolo [1, 2-b] quinazolin-12 (10H)-ones

CM Martínez-Viturro, D Domínguez

Index: Martinez-Viturro, Carlos M.; Dominguez, Domingo Tetrahedron Letters, 2007 , vol. 48, # 6 p. 1023 - 1026

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Citation Number: 22

Abstract

The synthesis of batracylin and related isoindolo [1, 2-b] quinazolin-12-ones from easily accessible o-acylanilines is reported. The preparation of these tetracyclic compounds through a Mitsunobu reaction followed by spontaneous cyclodehydration shows the ability of this methodology to afford good yields of a wide variety of diversely 7, 8, 9, 10-substituted isoindoloquinazolinones in two steps.