Total synthesis and antifungal evaluation of cyclic aminohexapeptides

…, SA Thomas, CM Yeung, KW Funk, V Kishore…

Index: Klein, Larry L.; Li, Leping; Chen, Hui-Ju; Curty, Cynthia B.; Degoey, David A.; Grampovnik, David J.; Leone, Christina L.; Thomas, Sheela A.; Yeung, Clinton M.; Funk, Kenneth W.; Kishore, Vimal; Lundell, Edwin O.; Wodka, Dariusz; Meulbroek, Jon A.; Alder, Jeffrey D.; Nilius, Angela M.; Lartey, Paul A.; Plattner, Jacob J. Bioorganic and Medicinal Chemistry, 2000 , vol. 8, # 7 p. 1677 - 1696

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Citation Number: 42

Abstract

The need for new therapies to treat systemic fungal infections continues to rise. Naturally occurring hexapeptide echinocandin B (1) has shown potent antifungal activity via its inhibition of the synthesis of β-1, 3 glucan, a key fungal cell wall component. Although this series of agents has been limited thus far based on their physicochemical characteristics, we have found that the synthesis of analogues bearing an aminoproline residue in the ' ...