Tetrahedron Letters

Azodicarbonyl dimorpholide (ADDM): an effective, versatile, and water-soluble Mitsunobu reagent

ME Lanning, S Fletcher

Index: Lanning, Maryanna E.; Fletcher, Steven Tetrahedron Letters, 2013 , vol. 54, # 35 p. 4624 - 4628

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Citation Number: 12

Abstract

Abstract One of the caveats of the Mitsunobu reaction is the often difficult and laborious purification of the reaction mixture. Herein, we show that azodicarbonyl dimorpholide (ADDM) is an effective and versatile Mitsunobu reagent, which, along with its reduced form ADDM-H 2, may be removed from the reaction mixture by a simple aqueous extraction. Furthermore, we demonstrate that the isolated ADDM-H 2 may be re-oxidized with silver (I ...