Tetrahedron letters

Aromatic nucleophilic substitutions under microwave irradiation

GV Salmoria, E Dall'Oglio, C Zucco

Index: Salmoria, Gean V.; Dall'Oglio, Evandro; Zucco, Cesar Tetrahedron Letters, 1998 , vol. 39, # 17 p. 2471 - 2474

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Citation Number: 25

Abstract

In order to study the effect of microwave irradiation over aromatic nucleophilic substitutions at atmospheric pressure and in a homogeneous medium, experiments with disubstituted- benzenes and the nucleophiles piperidine and potassium t-butoxide, in refluxing DMSO or DMF, were carried out. The aromatic nucleophilic substitutions under microwave irradiation were 2.7 to 12 times faster than under conventional reflux.