Synthetic communications

Enantioselective Synthesis of A Wieland-Miescher Ketone Bearing an Angular Hydroxymethyl Group

R Hanselmann, M Benn

Index: Hanselmann, Roger; Benn, Michael Synthetic Communications, 1996 , vol. 26, # 5 p. 945 - 961

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Citation Number: 17

Abstract

Abstract: The enatioselective synthesis of (R)-3,4,8,8a-tetrahydro-8a-allyl- 1,6-(2H,7H)-naphthaIenedione and the degradation of the angular ally1 group to a hydroxymethyl group are reported. ... Numerous terpenoidal natural products have been described in which a ... Biologtcally, the angular hydroxy methyl group is most likely formed via a ... Wieland-Miescher ketone derivatives bearing an angular hydroxymethyl ... Synthesized 4 and 2 via alkylation of a dihydrodimethoxybenzene