The Chemistry of Carbanions. XI. Michael Reactions with 2-Methylcyclopentanone and 2-Methylcyclohexanone1a

HO House, WL Roelofs, BM Trost

Index: House,H.O. et al. Journal of Organic Chemistry, 1966 , vol. 31, p. 646 - 655

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Citation Number: 32

Abstract

The reaction of 2-methylcyclopentanone with methyl acrylate and the reactions of 2- methylcyclohexanone with methyl acrylate, methyl propiolate, and the methyl cis-and trans-3- chloroacrylates have been studied. The predominant formation of 2, 2-disubstituted cycloalkanones as Michael products in certain of these reactions appears to be attributable to a combination of two factors. First, the positions of the relevant enolate anion equilibria ...