… of 5??[(2??methyl??5??nitro??1H??imidazol??1??yl) methyl]??1, 3, 4??oxadiazole??2 (3H) thione and N??substituted 2??amino??5??[(2??methyl??5??nitro??1H??imidazol??1??yl) methyl]??1, 3 …
J Mirzaei, H Pirelahi, M Amini…
Index: Mirzaei, Javad; Amini, Mohsen; Pirelahi, Hooshang; Shafiee, Abbas Journal of Heterocyclic Chemistry, 2008 , vol. 45, # 3 p. 921 - 925
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Citation Number: 10
Abstract
In general, 5-nitroimidazoles like metronidazole or ornidazole (Figure 1) are valuable drugs for treatment, of several protozoal diseases as well as for treating infections due to anaerobic bacteria [1]. The nitroimidazoles used therapeutically are 5-nitroimidazoles that have substituents at N-1 and C-2 but lack a substituent at C-4 [2], whereas the 4- nitroimidazoles have no significant therapeutic value [3-4]. Synthesis of biologically active ...
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