RCM Approach to Complex Polycyclic α??Hydroxy γ??Lactams: Synthesis of Indolizinones and Pyrroloazepinones

A Gómez??SanJuan, N Sotomayor…

Index: Gomez-Sanjuan, Asier; Sotomayor, Nuria; Lete, Esther European Journal of Organic Chemistry, 2013 , # 29 p. 6722 - 6732

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Citation Number: 4

Abstract

Abstract The allylmagnesium chloride addition/RCM sequence on N-alkenyl-substituted imides provides a mild access to indolizinone and pyrroloazepinone derivatives with the α- hydroxy-γ-lactam framework. The procedure can be applied to the asymmetric synthesis of this type of derivatives, by employing a 2-exo-hydroxy-10-bornylsulfinyl group as a chiral auxiliary. Further functionality can be introduced at the angular position through an α- ...