Synthesis

Facile Conversion of Thioamides into the Corresponding Amides in the Presence of Tetrabutylammonium Bromide

K Inamoto, M Shiraishi, K Hiroya, T Doi

Index: Inamoto, Kiyofumi; Shiraishi, Mitsugu; Hiroya, Kou; Doi, Takayuki Synthesis, 2010 , # 18 p. 3087 - 3090

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Citation Number: 4

Abstract

Amide groups occur widely in nature, and a large number of biologically active molecules, including drugs, natural products, and peptides possess amide groups. The development of methods for the efficient synthesis of amide bond containing molecules is therefore of great importance. Desulfurization of thioamides produces amides, and a number of methods for this transformation have been reported. [¹] [²] However, most of these methods suffer from several drawbacks such as ...

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