Tetrahedron Letters

Microwave assisted copper-free Sonogashira coupling/5-exo-dig cycloisomerization domino reaction: access to 3-(phenylmethylene) isoindolin-1-ones and related …

M Hellal, GD Cuny

Index: Hellal, Malik; Cuny, Gregory D. Tetrahedron Letters, 2011 , vol. 52, # 42 p. 5508 - 5511

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Citation Number: 50

Abstract

An efficient microwave assisted one-pot synthesis of substituted 3-(phenylmethylene) isoindolin-1-ones is reported via a copper-free Sonogashira coupling and a regioselective 5- exo-dig cycloisomerization. This domino reaction was also extended to other related heterocycles.

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