Halide-free ethylation of phenol by multifunctional catalysis using phosphinite ligands

MC Carrión, DJ Cole-Hamilton

Index: Carrion, M. Carmen; Cole-Hamilton, David J. Chemical Communications, 2006 , # 43 p. 4527 - 4529

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Citation Number: 9

Abstract

The formation of carbon–carbon bonds is a key component of many transformations in the pharmaceutical, agrochemical and organic chemical industries. Generally speaking, these transformations involve the reaction of alkyl or aryl halides with an alkyl or arylating agent, or with an alkene (Heck, Suzuki, Stille etc. couplings). In all these cases, the halogen is first introduced into one of the substrates and is then lost, necessitating extra synthetic steps and generating ...