Structure-activity studies of 5-[[4-(4, 5-dihydro-2-oxazolyl) phenoxy] alkyl]-3-methylisoxazoles: inhibitors of picornavirus uncoating

…, V Akullian, PM Carabateas, D Cutcliffe…

Index: Diana, Guy D.; Oglesby, Richard C.; Akullian, Vahan; Carabateas, Phillip M.; Cutcliffe, David; et al. Journal of Medicinal Chemistry, 1987 , vol. 30, # 2 p. 383 - 388

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Citation Number: 35

Abstract

The mode of action of compound 1 has been shown to be the inhibition of viral uncoating. 6 The role of uncoating in the replication of picornaviruses is graphically shown in Figure 1. After receptor-mediated adsorption of the virus to the cell membrane, the virion penetrates ...