Synthesis and biological evaluation of a new series of N-ylides as protein farnesyltransferase inhibitors

CM Abuhaie, A Ghinet, A Farce, J Dubois…

Index: Abuhaie, Cristina-Maria; Ghinet, Alina; Farce, Amaury; Dubois, Joelle; Rigo, Benoit; Bicu, Elena Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 21 p. 5887 - 5892

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Citation Number: 8

Abstract

Abstract A new family of 30 benzoylated N-ylides 4 and 5 was synthesized and evaluated for the inhibitory activity on human protein farnesyltransferase. Most of these novel compounds possessed in vitro inhibition potencies in the micromolar range. The nature of the ...