Synthesis and in vitro LTD4 antagonist activity of bicyclic and monocyclic cyclopentylurethane and cyclopentylacetamide N-arylsulfonyl amides

…, HS Shapiro, TP Maduskuie Jr, LA Cronk…

Index: Matassa; Brown; Bernstein; Shapiro; Maduskuie Jr.; Cronk; Vacek; Yee; Snyder; Krell; Lerman; Maloney Journal of Medicinal Chemistry, 1990 , vol. 33, # 9 p. 2621 - 2629

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Citation Number: 25

Abstract

The dissociation constants (KB) at the LTD, receptor on guinea pig trachea of a series of monocyclic and bicyclic cyclopentylurethane and cyclopentylacetamide N-arylsulfonyl amides have been measured. The KB was found to be remarkably tolerant of changes in the electronic constitution and lipophilicity of the bicyclic ring system (template).