Isosteres of Natural Phosphates. Methylene and Hydroxyrnethylene Analogues of Tyrosine O-Phosphate

E Nudelman, R Engel

Index: Nudelman, Ellen; Engel, Robert Phosphorus, Sulfur and Silicon and the Related Elements, 1996 , vol. 111, p. 162

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Abstract

Abstract The ability of phosphonic acid analogues isosteric with natural phosphate esters to Serve as inhibitors of enzymatic phosphate hydrolysis has been documented in a wide variety of systems. 1 The use of such an analogue in place of the natural phosphate ester provides a functionality which the enzyme may not be able to distinguish from the natural ester, but which is incapable of being hydrolyzed. In some instances the use of ...

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