Syntheses of Antitumor Morphinane Alkaloids, Sinococuline and 6-epi-, 7-epi-, and 6-epi-7-epi-Sinococuline, from Sinomenine
Y Hitotsuyanagi, K Nishimura, H Ikuta…
Index: Hitotsuyanagi, Yukio; Nishimura, Kunihiko; Ikuta, Hiroshi; Takeya, Koichi; Itokawa, Hideji Journal of Organic Chemistry, 1995 , vol. 60, # 14 p. 4549 - 4558
Full Text: HTML
Citation Number: 17
Abstract
We have previously reported2 the isolation and structure elucidation of an antitumor alkaloid, sinococuline (l), from the native Japanese plant Cocculus trilobus. Sinococuline (1) is characterized by a morphinane skeleton possessing a unique oxidation state on ring C and promising antitumor activity against animal tumor models. However, the variable content in the plant and the difficult isolation and purification process due to its highpolar, ...
Related Articles:
[Hitotsuyanagi, Yukio; Ikuta, Hiroshi; Nishimura, Kunihiko; Takeya, Koichi; Itokawa, Hideji Journal of the Chemical Society, Chemical Communications, 1994 , # 23 p. 2707 - 2708]
[Hitotsuyanagi, Yukio; Ikuta, Hiroshi; Nishimura, Kunihiko; Takeya, Koichi; Itokawa, Hideji Journal of the Chemical Society, Chemical Communications, 1994 , # 23 p. 2707 - 2708]
[Hitotsuyanagi, Yukio; Ikuta, Hiroshi; Nishimura, Kunihiko; Takeya, Koichi; Itokawa, Hideji Journal of the Chemical Society, Chemical Communications, 1994 , # 23 p. 2707 - 2708]
[Deng, Jing-Zhen; Zhao, Shou-Xun; Miao, Zhen-Chun Phytochemistry (Elsevier), 1992 , vol. 31, # 4 p. 1448 - 1450]