Enantioselective Copper (I/II)??Catalyzed Conjugate Addition of Nitro Esters to β, γ??Unsaturated α??Ketoesters

S Zhang, K Xu, F Guo, Y Hu, Z Zha…

Index: Zhang, Sheng; Xu, Kun; Guo, Fengfeng; Hu, Yanbin; Zha, Zhenggen; Wang, Zhiyong Chemistry - A European Journal, 2014 , vol. 20, # 4 p. 979 - 982

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Abstract

Abstract A highly enantioselective Michael addition of nitroacetates to β, γ-unsaturated α- ketoesters was developed by using chiral copper catalysts. The Michael addition products can be obtained in high yields with up to 99% ee. With these densely functionalized products, the chiral cyclic nitrones, which are important synthetic intermediates, can be obtained in one step.