DNA-targeting pyrroloquinoline-linked butenone and chalcones: Synthesis and biological evaluation

L Dalla Via, O Gia, G Chiarelotto, MG Ferlin

Index: Via, Lisa Dalla; Gia, Ornella; Chiarelotto, Gianfranco; Ferlin, Maria Grazia European Journal of Medicinal Chemistry, 2009 , vol. 44, # 7 p. 2854 - 2861

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Citation Number: 15

Abstract

A series of conjugates of α, β-unsaturated ketone systems, phenyl-butenone and diaryl- propenones (chalcones), with the tricyclic planar pyrroloquinoline nucleus were synthesised and evaluated for their anticancer properties. The aim was to target DNA by butenone and chalcones, and determine the occurrence of interactions with the macromolecule or related functional enzymes. The ability to inhibit cell growth was assayed on three human tumor ...