Synthesis and structure-activity relationships of new 7-[3-(fluoromethyl) piperazinyl]-and-(fluorohomopiperazinyl) quinolone antibacterials

…, P Bitha, NA Kuck, TJ Fenton, PJ Petersen…

Index: Ziegler, C. B.; Bitha, P.; Kuck, N. A.; Fenton, T. J.; Petersen, P. J.; Lin, Y.-i Journal of Medicinal Chemistry, 1990 , vol. 33, # 1 p. 142 - 146

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Citation Number: 26

Abstract

Some novel 6-fluoro-7-substituted-1, 4-dihydro-4-oxoquinoline-3-carboxylic acids have been prepared. At the N-1 position" standard" substitution was employed with the ethyl, cyclopropyl, and p-fluorophenyl groups being used. At C-7 the introduction of some novel piperazines was made. Most notably, 2-(fluoromethyl) piperazine (10) and hexahydr0-6- fluoro-lH-1, 4-diazepine (16, fluorohomopiperazine) at the quinolone C-7 position ...