Synthesis and biological activity of dispirotripiperazinium derivatives

…, NM Karimova, OV Kil'disheva, IL Knunyants

Index: Chernov, G. A.; Lisina, N. I.; Karimova, N. M.; Kil'disheva, O. V.; Knunyants, I. L. Pharmaceutical Chemistry Journal, 1987 , vol. 21, # 3 p. 207 - 210 Khimiko-Farmatsevticheskii Zhurnal, 1987 , vol. 21, # 3 p. 319 - 321

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Abstract

Reactions under mild conditions between compounds I and II and sodium thiosulfate, lithium thioacetate, and thiourea resulted in high yields of the corresponding bisthiosulfate (IVa and Va), thioacetyl (IVb and Vb) and isothiouronium (IVa) derivatives of the dispirotripiperazinium series in the form of dichlorides, dibromides, and internal salts (in the case of IVa and Na).