Heterodimers of histidine and amantadine as inhibitors for wild type and mutant M2 channels of influenza A

W Zhang, J Xu, F Liu, C Li, Y Jie, S Chen…

Index: Zhang, Wenjuan; Xu, Jing; Liu, Fang; Li, Chufang; Jie, Yanling; Chen, Shaopeng; Li, Zhiyuan; Liu, Jinsong; Chen, Ling; Zhou, Guochun Chinese Journal of Chemistry, 2010 , vol. 28, # 8 p. 1417 - 1423

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Citation Number: 7

Abstract

Abstract Inhibitors bearing the imidazole, adamantane and related structures were synthesized and tested against WT, S31N and S31N-L26I mutant M2 channels. Although amantadine (1) only inhibited WT M2 channel, compound 6 containing the imidazole and adamantane groups showed good inhibitory activity to WT and mutant M2 channels. The stereochemistry and basic pK a of α-amine are important for the activity of inhibitors and ...