Transkarbams with terminal branching as transdermal permeation enhancers

…, K Vávrová, T Holas, J Novotný, A Hrabálek

Index: Klimentova, Jana; Kosak, Petr; Vavrova, Katerina; Holas, Tomas; Novotny, Jakub; Hrabalek, Alexandr Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 5 p. 1712 - 1715

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Citation Number: 11

Abstract

Transkarbams (T) represent novel group of highly active, non-toxic transdermal permeation enhancers. This study was focused on the influence of small symmetrical terminal branching on their enhancing activity. Series of T with terminal methyl or ethyl branching was prepared and their permeation-enhancing activity was compared to that of their linear analogues. The results showed completely a different behaviour from similarly branched alcohols, ...