Non-peptidic small molecule inhibitors of XIAP

…, C Sun, ET Olejniczak, AE Wilson, RP Meadows…

Index: Park, Cheol-Min; Sun, Chaohong; Olejniczak, Edward T.; Wilson, Alan E.; Meadows, Robert P.; Betz, Stephen F.; Elmore, Steven W.; Fesik, Stephen W. Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 3 p. 771 - 775

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Citation Number: 66

Abstract

Non-peptidic small molecule SMAC mimetics were designed and synthesized that bind to the BIR3 domain of XIAP using structure-based design. Substituted five-membered heterocycles such as thiazoles and imidazoles were identified that serve as replacements for peptide fragments of the lead.

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