Tweezers with different bite: Increasing the affinity of synthetic receptors by varying the hinge part

…, M Broekema, AJ Brouwer, WC Still…

Index: Loewik, Dennis W. P. M.; Weingarten, W. David; Broekema, Matthias; Brouwer, Arwin J.; Still, W. Clark; Liskamp, Rob M. J. Angewandte Chemie - International Edition, 1998 , vol. 37, # 13-14 p. 1846 - 1850

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Citation Number: 55

Abstract

Abstract With preservation of selectivity, the hinge part of tweezerlike synthetic receptor molecules can be varied to achieve a higher affinity. The synthetic peptidosulfonamide receptor (below left; R= Disperse Red 1) with the bis (aminomethyl) benzoic acid hinge selectively bound the tripeptide shown below on the right (K a= 4100 M− 1). Combination of a diversity in the hinge part with that present in the tweezer arms will provide access to ...