The Journal of organic chemistry

Palladium-catalyzed decarboxylative coupling of alkynyl carboxylic acids and aryl halides

J Moon, M Jang, S Lee

Index: Moon, Jeongju; Jang, Mihee; Lee, Sunwoo Journal of Organic Chemistry, 2009 , vol. 74, # 3 p. 1403 - 1406

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Citation Number: 142

Abstract

2-Octynoic acid and phenylpropiolic acid were employed for the palladium-catalyzed decarboxylative coupling reaction and with a variety of aryl halides. The former needed 1, 4- bis (diphenylphosphino) butane (dppb) as a ligand and the latter tri-tert-butylphosphine (PtBu3), and both required 2 equiv of tetra-n-butylammonium fluoride (TBAF) for full conversion. These reactions showed high reactivities and tolerance of functional groups ...

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