Facile CuI-Catalyzed Arylation of Azoles and Amides Using Simple Enaminones as Efficient Ligands

C Cheng, G Sun, J Wan, C Sun

Index: Cheng, Cungui; Sun, Gonglei; Wan, Jieping; Sun, Cuirong Synlett, 2009 , # 16 p. 2663 - 2668

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Abstract

Abstract (E)-3-(Dimethylamino)-1-(2-hydroxyphenyl) prop-2-en-1-one was found to be an excellent ligand for copper-catalyzed N-arylation of azoles and amides with aryl halides under mild conditions. The reaction took place at 82 C in MeCN with broad functional-group compatibility. A combination of the ligand and CuI proved to be an efficient catalytic system to promote the coupling reactions of aryl halides with azoles and amides.