Asymmetric synthesis of β-fluoroaryl-β-amino acids

…, AM Fletcher, L Lv, PM Roberts, JE Thomson

Index: Davies, Stephen G.; Fletcher, Ai M.; Lv, Linlu; Roberts, Paul M.; Thomson, James E. Tetrahedron Asymmetry, 2012 , vol. 23, # 11-12 p. 910 - 925

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Citation Number: 2

Abstract

The conjugate addition of lithium (R)-N-benzyl-N-(α-methylbenzyl) amide to a range of β- fluoroaryl-α, β-unsaturated esters gave the corresponding β-amino esters with high diastereoselectivity and in good isolated yields. Sequential treatment of the resultant β- fluoroaryl-β-amino esters under optimised hydrogenolysis conditions, followed by ester hydrolysis with 2.0 M aq HCl, provided access to a range of β-fluoroaryl-β-amino acids in ...