Journal of medicinal chemistry

Synthetic Antigonadotropins. II

HH Fox, JT Gibas, HL Lee, A Boris

Index: Fox,H.H. et al. J. Med. Chem., 1964 , vol. 7, p. 790 - 792

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Citation Number: 4

Abstract

In an attempt to relate structure and antigonadotropin iwtivity, a series of changes were effected on the active triphenylethylene structures. These rhanges include:(I j substitution of a cycloalkyl group for one of i tic, benzene rings;(2) bridging two of the henzene rings to give fluorene, diben~ ocycloheptadieiie, and dibenzorycloheptatriene groups;(3) replacement of the ethylenic link with a cylopropyl group;(4) replacement of one of the aliphatic carbon ...