Synthesis and biological activity of benzylidene derivatives of imidazo [4, 5-g] indolizines

…, AG Ignatenko, BE Afanas' ev, VV Kirichenko…

Index: Yutilov, Yu. M.; Ignatenko, A. G.; Afanas'ev, B. E.; Kirichenko, V. V.; Orestenko, L. P.; Linenko, V. I. Pharmaceutical Chemistry Journal, 1989 , vol. 23, # 6 p. 490 - 493 Khimiko-Farmatsevticheskii Zhurnal, 1989 , vol. 23, # 6 p. 697 - 699

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Abstract

We synthesized for the first time imidazo[4,5-g]indolizines from the 5-acylmethyl salts of 4-alkyl derivatives of imidazo[4,5-c]pyridine [5], and some of its styryl derivatives exhibited in the tests high antifungal and antibacterial activity [6, 7]. The aim of the present work was to find among the benzylidene derivatives of imidazo[4,5-g]indolizine, com- pounds having a bacteriostatic and fungistatic activity. The benzylidene derivatives of imidazo[4,5-g]indolizine (IIa-k, Va, ...