Hemicholinium-3 congeners as potential antagonists to organophosphate-induced toxicity

JG Cannon, MF Sahin, JP Long, JR Flynn…

Index: Cannon, Joseph G.; Sahin, M. Fethi; Long, John Paul; Flynn, Jan R.; Bhatnagar, Ranbir K. Journal of Medicinal Chemistry, 1990 , vol. 33, # 2 p. 577 - 579

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Citation Number: 5

Abstract

A series of congeners of hemicholinium-3, in which the 1, 4-oxazinium rings of hemicholinium are replaced by pyrrolidine, piperidine, 1, 3-dioxane, or 1, 4-oxazine rings, is described. Several of the target compounds produced blockade of neuromuscular transmission in the rabbit, and three heterocyclic derivatives, 10, 11, and 13, significantly antagonized paraoxon-induced lethality in mice. 1, 3-Dioxane derivative 11 was an ...