Organic letters

… Rh (III)-catalyzed oxidative acylation of secondary benzamides with aldehydes and intramolecular cyclization: The direct synthesis of 3-hydroxyisoindolin-1-ones

S Sharma, E Park, J Park, IS Kim

Index: Sharma, Satyasheel; Park, Eonjeong; Park, Jihye; Kim, In Su Organic Letters, 2012 , vol. 14, # 3 p. 906 - 909

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Citation Number: 93

Abstract

The rhodium-catalyzed oxidative acylation between secondary benzamides and aryl aldehydes via sp2 C–H bond activation followed by an intramolecular cyclization is described. This method results in the direct and efficient synthesis of 3-hydroxyisoindolin-1- one building blocks.