The. alpha.-and. beta.-deuterium kinetic isotope effects on the inactivation of the general acyl-coenzyme A dehydrogenase from pig kidney by (2- …

JE Baldwin, WC Widdison

Index: Baldwin, John E.; Widdison, Wayne C. Journal of the American Chemical Society, 1992 , vol. 114, # 6 p. 2245 - 2251

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Citation Number: 28

Abstract

Abstract: Seven deuterium-labeled and unlabeled forms of (2-methylenecyclopropane) acetyl-CoA (MCPA-CoA) have been employed in kinetic studies to assess a-and &deuterium isotope effects on the inactivation of the general acyl-CoA dehydrogenase from pig kidney. The racemic forms of a-d2-MCPA-CoA and Pd-MCPA-CoA do not show any significant kinetic isotope effects. When inactivations of the enzyme caused by (R)-MCPA-CoA and ...

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