Tetrahedron letters

One-pot three steps synthesis of cerpegin

D Villemin, L Liao

Index: Villemin, Didier; Liao, Liang Tetrahedron Letters, 1996 , vol. 37, # 48 p. 8733 - 8734

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Citation Number: 28

Abstract

Cerpegin 1 was synthesized in a one-pot reaction at room temperature catalysed by cesium carbonate with an overall of 75% yield. 3-Hydroxy-3-methyl-2-butanone 2 reacted with diethyl malonate 3 to give 2-ethoxycarbonyl-3, 4, 4-trimethyl-2-buten-4-olide 4. Then 4 with s- triazine gave to 1, 1-dimethylfuro [3, 4-c] pyridine-3, 4 (1H, 5H)-dione5 and which was alkylated with methyliodide to cerpegin.

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